(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

Base Information

• Chemical Name: (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester
• CAS No.: 339220-94-9
• Molecular Formula: C₃₈H₄₈INO₆
• Molecular Weight: 741.707
• Mol file: 339220-94-9.mol

Synonyms:(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

Chemical Property of (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

There total 3 articles about (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-methyl 2-amino-3-(4-iodophenyl)propanoate (113850-77-4) + (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester (339220-93-8) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester (339220-94-9)

Guidance literature:

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1021/ol015572i

Reference yield:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester (339220-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA

2: 70 percent / TBTU; NMM / dimethylformamide / 6 h / 0 - 20 °C

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/ol015572i

Reference yield:

1-(benzyloxy)-4-(3-iodopropyl)benzene (191407-39-3) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester (339220-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LDA

2: 70 percent / TBTU; NMM / dimethylformamide / 6 h / 0 - 20 °C

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium diisopropyl amide; In N,N-dimethyl-formamide;

DOI:10.1021/ol015572i

upstream raw materials:

(S)-methyl 2-amino-3-(4-iodophenyl)propanoate

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid

1-(benzyloxy)-4-(3-iodopropyl)benzene

Downstream raw materials:

(2S,3R)-2-[3-(4-Hydroxy-phenyl)-propyl]-3-{(S)-1-methoxycarbonyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-5-methyl-hexanoic acid tert-butyl ester

C₃₁H₄₄BNO₈

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-{(S)-1-methoxycarbonyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethylcarbamoyl}-5-methyl-hexanoic acid tert-butyl ester