(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

Base Information

• Chemical Name: (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester
• CAS No.: 339220-93-8
• Molecular Formula: C₂₈H₃₈O₅
• Molecular Weight: 454.607
• Mol file: 339220-93-8.mol

Synonyms:(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

Chemical Property of (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

There total 1 articles about (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid (112245-04-2) + 1-(benzyloxy)-4-(3-iodopropyl)benzene (191407-39-3) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester (339220-93-8) + (2R,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester

Guidance literature:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid; With lithium diisopropyl amide;

1-(benzyloxy)-4-(3-iodopropyl)benzene; Further stages.;

DOI:10.1021/ol015572i

Reference yield: 72.0%

3-iodo-L-tyrosine methyl ester (70277-02-0) + (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester (339220-93-8) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-hydroxy-3-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester (339220-96-1)

Guidance literature:

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1021/ol015572i

Reference yield: 70.0%

(S)-methyl 2-amino-3-(4-iodophenyl)propanoate (113850-77-4) + (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-isobutyl-succinic acid 1-tert-butyl ester (339220-93-8) → (2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester (339220-94-9)

Guidance literature:

With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1021/ol015572i

upstream raw materials:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-4-methylpentanoic acid

1-(benzyloxy)-4-(3-iodopropyl)benzene

Downstream raw materials:

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[2-(4-bromo-phenyl)-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(4-hydroxy-3-iodo-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester

(2S,3R)-2-[3-(4-Benzyloxy-phenyl)-propyl]-3-[(S)-2-(3-iodo-4-methoxy-phenyl)-1-methoxycarbonyl-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester