2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

Base Information

Chemical Name:2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole
CAS No.:1296868-34-2
Molecular Formula:C₁₈H₁₅F₂NO₂S
Molecular Weight:347.385
Hs Code.:

Synonyms:2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

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Chemical Property of 2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

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Technology Process of 2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

There total 2 articles about 2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1296868-24-0
4-nitrobut-1-yne

: 1296868-26-2
N-[(3,5-difluorophenyl)methylene]-4-methylbenzenesulfonamide

: 1296868-34-2
2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

Guidance literature:: 4-nitrobut-1-yne; N-[(3,5-difluorophenyl)methylene]-4-methylbenzenesulfonamide; With potassium tert-butylate; In methanol; at 20 ℃; for 8h; Inert atmosphere;

With gold(III) chloride; In methanol; at 70 ℃; for 36h; Inert atmosphere; Darkness;
DOI:10.1039/c1cc10751h

Reference yield:

: 32085-88-4
3,5-difluorobenzaldehyde

: 70-55-3
toluene-4-sulfonamide

: 1296868-34-2
2-(3,5-difluorophenyl)-5-methyl-1-[(4-methylphenyl)sulfonyl]-1H-pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetraethoxy orthosilicate / 3 h / 170 °C / Dean-Stark trap; Inert atmosphere

2.1: potassium tert-butylate / methanol / 8 h / 20 °C / Inert atmosphere

2.2: 36 h / 70 °C / Inert atmosphere; Darkness

With tetraethoxy orthosilicate; potassium tert-butylate; In methanol; 2.1: Mannich reaction;
DOI:10.1039/c1cc10751h