N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Base Information

Chemical Name:N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide
CAS No.:1262786-44-6
Molecular Formula:C₃₃H₄₀N₄O₂S
Molecular Weight:556.772
Hs Code.:

Synonyms:N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

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Chemical Property of N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

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Technology Process of N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

There total 6 articles about N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1262786-43-5
N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

: 74-88-4
methyl iodide

: 1262786-44-6
N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide; With sodium hydride; In tetrahydrofuran; Pionier 2076; at 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; Pionier 2076; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1262786-66-2
2-methyl-4-[3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutanenitrile

: 1262786-44-6
N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

3: sodium hydride

With ammonium hydroxide; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 123064-05-1
3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester

: 1262786-44-6
N-methyl-N-{2-methyl-4-[(1R,5S)-3-(2-methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]-2-phenylbutyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

5: sodium hydride

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030