3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime

Base Information

• Chemical Name: 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime
• CAS No.: 281681-21-8
• Molecular Formula: C₂₄H₃₆BNO₅
• Molecular Weight: 429.365
• Mol file: 281681-21-8.mol

Synonyms:3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime

Chemical Property of 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime

There total 9 articles about 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1S,2S)-1,2-Bis(1-methoxycyclopentyl)ethane-1,2-diol (153562-86-8) + 3-(1,3,6,2-Dioxazaborocan-2-yl)propiophenone O-methyloxime loxime → 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime (281681-21-8)

Guidance literature:

With hydrogenchloride; In chloroform; at 20 ℃;

DOI:10.1039/b004573j

Reference yield: 90.0%

(1S,2S)-1,2-Bis(1-methoxycyclopentyl)ethane-1,2-diol (153562-86-8) + 3-[1,3,6,2]dioxazaborocan-2-yl-1-phenyl-propan-1-one O-methyl-oxime (316821-53-1) → 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime (281681-21-8)

Guidance literature:

With hydrogenchloride; In chloroform;

DOI:10.1016/S0040-4039(00)00179-9

Reference yield: 21.0%

(E)-acetophenone O-methyloxime (15754-20-8) + (4S,5S)-2-Iodomethyl-4,5-bis(1-methoxycyclopentyl)-1,3,2-dioxoborolane (316821-51-9) → 3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone O-methyloxime (281681-21-8)

Guidance literature:

(E)-acetophenone O-methyloxime; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h;

(4S,5S)-2-Iodomethyl-4,5-bis(1-methoxycyclopentyl)-1,3,2-dioxoborolane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1039/b004573j

upstream raw materials:

(1S,2S)-1,2-Bis(1-methoxycyclopentyl)ethane-1,2-diol

3-[1,3,6,2]dioxazaborocan-2-yl-1-phenyl-propan-1-one O-methyl-oxime

(E)-acetophenone O-methyloxime

(4S,5S)-2-Iodomethyl-4,5-bis(1-methoxycyclopentyl)-1,3,2-dioxoborolane

Downstream raw materials:

(S)-3-amino-3-phenylpropanol

3-[(4S,5S)-4,5-Bis-(1-methoxy-cyclopentyl)-[1,3,2]dioxaborolan-2-yl]-1-phenyl-propylamine

3-[(4S,5S)-4,5-Bis(1-methoxycyclopentyl)-1,3,2-dioxoborolan-2-yl]propiophenone

1-acetoxy-3-acetylamino-3-phenylpropane