3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate

Base Information

• Chemical Name: 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate
• CAS No.: 191977-94-3
• Molecular Formula: C₆₂H₆₂FN₄O₁₅P
• Molecular Weight: 1153.16
• Mol file: 191977-94-3.mol

Synonyms:3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate

Chemical Property of 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate

There total 5 articles about 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphoroselenoate (151782-59-1) → 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate (191977-94-3)

Guidance literature:

With silver fluoride; In acetonitrile; for 1h;

DOI:10.1016/S0968-0896(01)00025-6

Reference yield:

C62H63N4O15PS → 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate (191977-94-3)

Guidance literature:

With triethylamine tris(hydrofluoride); iodine; triethylamine; In acetonitrile; for 0.166667h; Yield given;

DOI:10.1039/a701728f

Reference yield:

C62H63N4O15PSe → 3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-phosphorofluoridate (191977-94-3)

Guidance literature:

With triethylamine tris(hydrofluoride); iodine; triethylamine; In acetonitrile; for 0.166667h; Yield given;

DOI:10.1039/a701728f

upstream raw materials:

3',5'-O,O-bis(dimethoxytrityl)-dithymidilyl-3',5'-Se-methyl phosphoroselenoate

5'-O-(4-4'-dimethoxytrityl)thymidine

5'-O-(4,4'-dimethoxytrityl)-thymidine-3'-O-(2-seleno-1,3,2-oxathiaphospholane)