4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

Chemical Name:4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:1292220-35-9
Molecular Formula:C₃₇H₄₂N₆O₉
Molecular Weight:714.775
Hs Code.:

4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Synonyms:4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of 4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of 4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 7 articles about 4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 201230-82-2
carbon monoxide

: 1292220-33-7
{4-[2-(4-bromo-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-6-yl]-benzyl}-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester

: 1292220-35-9
4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: With triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dimethyl sulfoxide; at 80 ℃; for 16h; Sealed tube;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1292220-35-9
4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 2.5 h / 80 °C

1.2: 0 - 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 80 °C / Inert atmosphere

4.1: sodium methylate; ethanol; methanol / 38 h / Reflux

5.1: triethylamine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / dimethyl sulfoxide / 16 h / 80 °C / Sealed tube

With methanol; potassium phosphate; ethanol; sodium methylate; potassium acetate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1292220-35-9
4-[6-(4-{[tert-butoxycarbonyl-(3-tert-butoxycarbonylamino-propyl)-amino]-methyl}-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-2-yl]-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / toluene / 2.5 h / 80 °C

1.2: 0 - 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 80 °C / Inert atmosphere

4.1: sodium methylate; ethanol; methanol / 38 h / Reflux

5.1: triethylamine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / dimethyl sulfoxide / 16 h / 80 °C / Sealed tube

With methanol; potassium phosphate; ethanol; sodium methylate; potassium acetate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;