Technology Process of 2,3-bis(benzyloxy)-2,5-difluorophenatholamine
There total 7 articles about 2,3-bis(benzyloxy)-2,5-difluorophenatholamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
for 3h;
Yield given;
Heating;
DOI:10.1021/jm00076a024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / K2CO3 / acetone / Heating
2: 1.) n-BuLi, 2.) trimethyl borate, 3.) 30percent aq. H2O2
3: 88 percent / K2CO3 / acetone / Heating
4: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 1 h
5: ZnI2 / CHCl3 / Ambient temperature
6: LiAlH4 / diethyl ether / 3 h / Heating
With
lithium aluminium tetrahydride; n-butyllithium; Trimethyl borate; dihydrogen peroxide; potassium carbonate; zinc(II) iodide;
In
diethyl ether; chloroform; acetone;
DOI:10.1021/jm00076a024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / K2CO3 / acetone / Heating
2: 1.) n-BuLi, 2.) trimethyl borate, 3.) 30percent aq. H2O2
3: 88 percent / K2CO3 / acetone / Heating
4: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 1 h
5: ZnI2 / CHCl3 / Ambient temperature
6: LiAlH4 / diethyl ether / 3 h / Heating
With
lithium aluminium tetrahydride; n-butyllithium; Trimethyl borate; dihydrogen peroxide; potassium carbonate; zinc(II) iodide;
In
diethyl ether; chloroform; acetone;
DOI:10.1021/jm00076a024
