Technology Process of 1-(benzyloxy)-2,5-difluorobenzene
There total 1 articles about 1-(benzyloxy)-2,5-difluorobenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi, 2.) trimethyl borate, 3.) 30percent aq. H2O2
2: 88 percent / K2CO3 / acetone / Heating
3: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 1 h
4: ZnI2 / CHCl3 / Ambient temperature
5: LiAlH4 / diethyl ether / 3 h / Heating
6: 74 percent / H2 / 10percent Pd/C / methanol / 6 h / 2068.6 Torr
With
lithium aluminium tetrahydride; n-butyllithium; Trimethyl borate; hydrogen; dihydrogen peroxide; potassium carbonate; zinc(II) iodide;
palladium on activated charcoal;
In
methanol; diethyl ether; chloroform; acetone;
DOI:10.1021/jm00076a024
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) n-BuLi, 2.) trimethyl borate, 3.) 30percent aq. H2O2
2: 88 percent / K2CO3 / acetone / Heating
3: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 1 h, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 1 h
4: ZnI2 / CHCl3 / Ambient temperature
5: LiAlH4 / diethyl ether / 3 h / Heating
6: 85 percent / 4 h / Heating
7: 51 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
8: 39 percent / H2 / 10percent Pd/C / methanol / 7 h / 2068.6 Torr
With
lithium aluminium tetrahydride; n-butyllithium; Trimethyl borate; hydrogen; dihydrogen peroxide; potassium carbonate; zinc(II) iodide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; chloroform; acetone;
DOI:10.1021/jm00076a024
