18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane

Base Information

• Chemical Name: 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane
• CAS No.: 87338-16-7
• Molecular Formula: C₃₂H₄₂N₂O₈S₂
• Molecular Weight: 646.826
• Mol file: 87338-16-7.mol

Synonyms:18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane

Chemical Property of 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane

There total 3 articles about 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1,14-dibromo-3,6,9,12-tetraoxatetradecane (57602-02-5) + 1,3-bis<<(p-tolylsulfonyl)amino>methyl>benzene (87338-18-9) → 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane (87338-16-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1021/jo00175a022

Reference yield:

1,3-di(aminomethyl)benzene (1477-55-0) → 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane (87338-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / NaOH / H₂O; CH₂Cl₂

2: 46 percent / cesium carbonate / dimethylformamide / 60 °C

With sodium hydroxide; caesium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00175a022

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 18,20-benzo-1,16-bis(4-tolylsulfonyl)-1,16-diaza-4,7,10,13-tetraoxacyclouncosane (87338-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / NaOH / H₂O; CH₂Cl₂

2: 46 percent / cesium carbonate / dimethylformamide / 60 °C

With sodium hydroxide; caesium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00175a022

upstream raw materials:

1,14-dibromo-3,6,9,12-tetraoxatetradecane

1,3-bis<<(p-tolylsulfonyl)amino>methyl>benzene

1,3-di(aminomethyl)benzene

p-toluenesulfonyl chloride