87338-18-9Relevant academic research and scientific papers
Chloride-Mediated Apoptosis-Inducing Activity of Bis(sulfonamide) Anionophores
Saha, Tanmoy,Hossain, Munshi Sahid,Saha, Debasis,Lahiri, Mayurika,Talukdar, Pinaki
, p. 7558 - 7567 (2016)
Transmembrane anion transport modality is enjoying a renewed interest because of recent advances toward anticancer therapy. Here we show bis(sulfonamides) as efficient receptors for selective Cl- ion binding and transport across lipid bilayer m
Isolation of Key Organometallic Aryl-Co(III) Intermediates in Cobalt-Catalyzed C(sp2)-H Functionalizations and New Insights into Alkyne Annulation Reaction Mechanisms
Planas, Oriol,Whiteoak, Christopher J.,Martin-Diaconescu, Vlad,Gamba, Ilaria,Luis, Josep M.,Parella, Teodor,Company, Anna,Ribas, Xavi
, p. 14388 - 14397 (2016)
The selective annulation reaction of alkynes with substrates containing inert C-H bonds using cobalt as catalyst is currently a topic attracting significant interest. Unfortunately, the mechanism of this transformation is still relatively poorly understoo
Synthesis, molecular docking, and QSAR study of bis-sulfonamide derivatives as potential aromatase inhibitors
Leechaisit, Ronnakorn,Pingaew, Ratchanok,Prachayasittikul, Veda,Worachartcheewan, Apilak,Prachayasittikul, Supaluk,Ruchirawat, Somsak,Prachayasittikul, Virapong
, (2019/08/14)
A library of bis-sulfonamides (9–26) were synthesized and tested for their aromatase inhibitory activities. Interestingly, all bis-sulfonamide derivatives inhibited the aromatase with IC50 range of 0.05–11.6 μM except for compound 23. The analo
Synthesis of Aza Macrocycles by Nucleophilic Ring Closure with Cesium Tosylamides
Vriesema, Bindert K.,Buter, Jan,Kellogg, Richard M.
, p. 110 - 113 (2007/10/02)
Long-chain diamines as their bis tosylamide derivatives are deprotonated by Cs2CO3 in dimethylformamide solution to give the dicesium salts.These react smoothly with various dibromides or dimesylates to afford the cyclic diamines as their tosyl derivatives.The yields, depending on the size of the ring, range between 25percent and 95percent of isolated product.The largest ring made, 1,12-diazaoctacosane (as the tosylamide derivative) was isolated in 60percent yield.The tosyl groups are readily removed with sodium amalgam in Na2HPO4-buffered methanolic solution.Chiral macrocyclic amines have also been prepared by using this cesium salt method.
