N-(4-formylbenzoyl)doxorubicin

Base Information

Chemical Name:N-(4-formylbenzoyl)doxorubicin
CAS No.:928838-77-1
Molecular Formula:C₃₅H₃₃NO₁₃
Molecular Weight:675.646
Hs Code.:

Synonyms:N-(4-formylbenzoyl)doxorubicin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-formylbenzoyl)doxorubicin

Chemical Property:

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Technology Process of N-(4-formylbenzoyl)doxorubicin

There total 6 articles about N-(4-formylbenzoyl)doxorubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 23214-92-8
doxorubicin

: 619-66-9
4-Carboxybenzaldehyde

: 928838-77-1
N-(4-formylbenzoyl)doxorubicin

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 23 ℃; for 12h; Product distribution / selectivity;

Reference yield:

: 928838-76-0
C₄₀H₄₁N₃O₁₃

: 288-32-4
1H-imidazole

: 64-17-5
ethanol

: 928838-77-1
N-(4-formylbenzoyl)doxorubicin

Guidance literature:: In water; dimethyl sulfoxide; at 37 ℃; pH=5.5; Product distribution / selectivity; 2-[N-morpholino]ethanesulfonic acid (MES) buffer;

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 928838-77-1
N-(4-formylbenzoyl)doxorubicin

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 36 h / Reflux

2.1: hydrogenchloride / water / 24 h / Reflux

3.1: acetyl chloride; thionyl chloride / 1 h / Inert atmosphere; Reflux

4.1: sodium hydride / tetrahydrofuran / 1 h

4.2: 12 h / 23 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 23 °C

5.2: 12 h / 23 °C

6.1: water; dimethyl sulfoxide / 37 °C / pH 5.5 / 2-[N-morpholino]ethanesulfonic acid (MES) buffer

With hydrogenchloride; thionyl chloride; water; sodium hydride; acetyl chloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;