3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

Base Information

Chemical Name:3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide
CAS No.:444731-57-1
Molecular Formula:C₂₀H₂₁N₇O₂S
Molecular Weight:423.498
Hs Code.:

Synonyms:3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

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Chemical Property of 3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

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Technology Process of 3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

There total 6 articles about 3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 444731-80-0
N-(2-chloropyrimidin-4-yl)-N,1,2-trimethyl-1H-benzimidazol-5-amine

: 98-18-0
m-aminobenzenesulfonamide

: 444731-57-1
3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 80 ℃; Inert atmosphere;

Reference yield:

: 191728-95-7
N-(2-chloropyrimidin-4-yl)-2-methyl-1H-benzo[d]imidazol-5-amine

: 98-18-0
m-aminobenzenesulfonamide

: 74-88-4
methyl iodide

: 444731-57-1
3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

: 1042366-90-4
3-({4-[(1,2-dimethyl-1H-benzimidazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)benzenesulfonamide

Guidance literature:: N-(2-chloropyrimidin-4-yl)-2-methyl-1H-benzo[d]imidazol-5-amine; methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

m-aminobenzenesulfonamide; With hydrogenchloride; In water; isopropyl alcohol; at 80 ℃; for 16h;
DOI:10.1021/jm800566m

Reference yield:

: 3527-19-3
1,2-dimethyl-1H-benzo[d]imidazole-5-amine

: 444731-57-1
3-({4-[(1,2-dimethyl-1H-benzimidazol-5-yl)(methyl)amino]pyrimidin-2-yl}amino)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; ethanol / 80 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: hydrogenchloride / water; isopropyl alcohol / 80 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;