4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

Base Information

Chemical Name:4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole
CAS No.:1416970-68-7
Molecular Formula:C₂₈H₃₀FN₃O₃S
Molecular Weight:507.629
Hs Code.:

Synonyms:4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

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Chemical Property of 4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

Chemical Property:

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Technology Process of 4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

There total 5 articles about 4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1-(phenylsulfonyl)-4-(1-piperazinyl)-1H-indole hydrochloride

: 81936-77-8
1-(4-chlorobutoxy)-4-fluorobenzene

: 1416970-68-7
4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 8h;
DOI:10.1016/j.physbeh.2013.05.042

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1416970-68-7
4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: potassium carbonate; potassium iodide / acetonitrile / 8 h

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1016/j.physbeh.2013.05.042

Reference yield:

: 252978-89-5
4-(1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1416970-68-7
4-(4-(4-(4-fluorophenoxy)butyl)piperazin-1-yl)-1-(phenylsulfonyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: potassium carbonate; potassium iodide / acetonitrile / 8 h

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1016/j.physbeh.2013.05.042