3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid

Base Information

• Chemical Name: 3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid
• CAS No.: 216481-95-7
• Molecular Formula: C₁₁H₉Cl₂NO₅
• Molecular Weight: 306.102
• Mol file: 216481-95-7.mol

Synonyms:3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid

Chemical Property of 3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid

There total 1 articles about 3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-amino-5-hydroxybenzoic acid (76045-71-1) + chloroacetyl chloride (79-04-9) → 3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid (216481-95-7)

Guidance literature:

With pyridine; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00775-3

Reference yield:

3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid (216481-95-7) → Chloro-acetic acid 3-(2-chloro-acetylamino)-5-chlorocarbonyl-phenyl ester

Guidance literature:

With thionyl chloride; In toluene; for 1.5h; Heating;

DOI:10.1016/S0040-4020(98)00775-3

Reference yield:

3-(2-Chloro-acetoxy)-5-(2-chloro-acetylamino)-benzoic acid (216481-95-7) → C50H58Cl2N8O12

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 1.5 h / Heating

2: Et₃N / toluene; CH₂Cl₂ / 16 h / Ambient temperature

With thionyl chloride; triethylamine; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(98)00775-3

upstream raw materials:

3-amino-5-hydroxybenzoic acid

chloroacetyl chloride