N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

Base Information

Chemical Name:N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide
CAS No.:1391048-48-8
Molecular Formula:C₂₀H₂₃N₅O
Molecular Weight:349.436
Hs Code.:

Synonyms:N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

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Chemical Property of N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

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Technology Process of N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

There total 5 articles about N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 288-88-0
1,2,4-Triazole

: 1391048-55-7
3-hydroxy-2,2,N-trimethyl-3-(4-phenylaminophenyl)propionamide

: 1391048-48-8
N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

Guidance literature:: With 1,1'-Carbonyl-di-(1,2,4-triazole); In acetonitrile; for 24h; Reflux;
DOI:10.1016/j.bmc.2012.05.076

Reference yield:

: 1202273-87-7
3-(4-aminophenyl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 1391048-48-8
N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / Reflux

2.2: pH 3

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: 1,1'-Carbonyl-di-(1,2,4-triazole) / acetonitrile / 24 h / Reflux

With 1,1'-Carbonyl-di-(1,2,4-triazole); pyridine; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 1.1: Suzuki reaction;
DOI:10.1016/j.bmc.2012.05.076

Reference yield:

: 1283087-62-6
3-hydroxy-2,2-dimethyl-3-(4-phenylaminophenyl)propionic acid methyl ester

: 1391048-48-8
N,2,2-trimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / Reflux

1.2: pH 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: 1,1'-Carbonyl-di-(1,2,4-triazole) / acetonitrile / 24 h / Reflux

With 1,1'-Carbonyl-di-(1,2,4-triazole); benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2012.05.076