[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

Base Information

Chemical Name:[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide
CAS No.:1246364-34-0
Molecular Formula:C₃₇H₄₁O₂PSi
Molecular Weight:576.791
Hs Code.:

Synonyms:[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

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Chemical Property of [2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

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Technology Process of [2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

There total 8 articles about [2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1246364-32-8
(E)-2-[(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethanol

: 829-85-6
diphenylphosphane

: 1246364-34-0
[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

Guidance literature:: (E)-2-[(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethanol; With n-butyllithium; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

With dihydrogen peroxide; In dichloromethane; water; at 0 ℃; for 1h;

Reference yield:

: 1279708-81-4
[(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]acetic acid methyl ester

: 1246364-34-0
[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - -40 °C / Inert atmosphere

1.3: Zorbax-Sil column / Resolution of racemate

2.1: n-butyllithium; p-toluenesulfonyl chloride / hexane; tetrahydrofuran / 0 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

2.3: 1 h / 0 °C

With n-butyllithium; diisobutylaluminium hydride; p-toluenesulfonyl chloride; In tetrahydrofuran; hexane; dichloromethane; toluene;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1246364-34-0
[2-[(Z)-(R)-3'-[(tert-butyldiphenylsilyl)oxy]-4'-methylene-cyclohexylidene]ethyl]diphenyl phosphine oxide

Guidance literature:: Multi-step reaction with 7 steps

1.1: L-proline; Nitrosobenzene / chloroform / 26 h / 4 - 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0 - 20 °C

3.2: 5 h / -78 - 20 °C

4.1: iron(III) chloride hexahydrate / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 - -40 °C / Inert atmosphere

6.3: Zorbax-Sil column / Resolution of racemate

7.1: n-butyllithium; p-toluenesulfonyl chloride / hexane; tetrahydrofuran / 0 °C / Inert atmosphere

7.2: 0 °C / Inert atmosphere

7.3: 1 h / 0 °C

With 1H-imidazole; n-butyllithium; iron(III) chloride hexahydrate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; Nitrosobenzene; p-toluenesulfonyl chloride; L-proline; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 3.1: Wittig Reaction / 5.1: Peterson reaction;