1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate
CAS No.:1179522-57-6
Molecular Formula:C₃₀H₄₄F₃N₃O₄S
Molecular Weight:599.758
Hs Code.:

1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

Synonyms:1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

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Technology Process of 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

There total 5 articles about 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179522-56-5
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

: 1179522-57-6
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

Guidance literature:: With Lawessons reagent; In 2-methyltetrahydrofuran; at 70 ℃; for 4h;
DOI:10.1021/op2000095

Reference yield:

: 1005407-63-5
4-(n-octyloxy)-3-(trifluoromethyl)benzoic acid

: 1179522-57-6
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran / 25 °C / Large scale reaction

1.2: 25 °C / Large scale reaction

2.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran; isopropyl alcohol / 1.5 h / 40 °C

2.2: 3 h / 40 °C

3.1: Lawessons reagent / 2-methyltetrahydrofuran / 4 h / 70 °C

With Lawessons reagent; 1,1'-carbonyldiimidazole; In 2-methyltetrahydrofuran; isopropyl alcohol;
DOI:10.1021/op2000095

Reference yield:

: 111-87-5
octanol

: 1179522-57-6
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-{5-[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 24 h / 55 - 60 °C / Large scale reaction

2.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran / 25 °C / Large scale reaction

2.2: 25 °C / Large scale reaction

3.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran; isopropyl alcohol / 1.5 h / 40 °C

3.2: 3 h / 40 °C

4.1: Lawessons reagent / 2-methyltetrahydrofuran / 4 h / 70 °C

With Lawessons reagent; sodium hexamethyldisilazane; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 2-methyltetrahydrofuran; isopropyl alcohol;
DOI:10.1021/op2000095