1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate
CAS No.:1179522-56-5
Molecular Formula:C₃₀H₄₆F₃N₃O₆
Molecular Weight:601.707
Hs Code.:

1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

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Technology Process of 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

There total 5 articles about 1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005407-66-8
4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide

: 1179522-58-7,1686957-60-7
(2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid

: 1179522-56-5
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: (2R,4S)-2-tert-butyl-3-tert-butoxycarbonyl-4-methyl-1,3-oxazolidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In 2-methyltetrahydrofuran; isopropyl alcohol; at 40 ℃; for 1.5h;

4-(n-octyloxy)-3-(trifluoromethyl)benzohydrazide; In 2-methyltetrahydrofuran; isopropyl alcohol; at 40 ℃; for 3h;
DOI:10.1021/op2000095

Reference yield:

: 1005407-63-5
4-(n-octyloxy)-3-(trifluoromethyl)benzoic acid

: 1179522-56-5
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran / 25 °C / Large scale reaction

1.2: 25 °C / Large scale reaction

2.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran; isopropyl alcohol / 1.5 h / 40 °C

2.2: 3 h / 40 °C

With 1,1'-carbonyldiimidazole; In 2-methyltetrahydrofuran; isopropyl alcohol;
DOI:10.1021/op2000095

Reference yield:

: 111-87-5
octanol

: 1179522-56-5
1,1-dimethylethyl (2R,4S)-2-(1,1-dimethylethyl)-4-methyl-4-[(2-{[4-(n-octyloxy)-3-(trifluoromethyl)phenyl]carbonyl}-hydrazino)carbonyl]-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 24 h / 55 - 60 °C / Large scale reaction

2.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran / 25 °C / Large scale reaction

2.2: 25 °C / Large scale reaction

3.1: 1,1'-carbonyldiimidazole / 2-methyltetrahydrofuran; isopropyl alcohol / 1.5 h / 40 °C

3.2: 3 h / 40 °C

With sodium hexamethyldisilazane; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 2-methyltetrahydrofuran; isopropyl alcohol;
DOI:10.1021/op2000095