5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

Base Information

Chemical Name:5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline
CAS No.:1283526-70-4
Molecular Formula:C₁₄H₂₁F₃N₂O
Molecular Weight:290.329
Hs Code.:

Synonyms:5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

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Chemical Property of 5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

Chemical Property:

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Technology Process of 5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

There total 5 articles about 5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1283526-67-9
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

: 1283526-70-4
5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

Reference yield:

: 2725-53-3
2-hydroxy-5-t-butylbenzaldehyde

: 1283526-70-4
5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitronium tetrafluoborate / acetonitrile / 1 h / -40 - -20 °C

1.2: 15 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2.2: 2 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 14 h / 20 °C

4.1: triethylamine / titanium(IV) isopropylate / ethanol / 20 °C

4.2: 0 - 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

With nitronium tetrafluoborate; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; triethylamine; titanium(IV) isopropylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1283526-57-7
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol

: 1283526-70-4
5-tert-butyl-2-methoxy-3-(2,2,2-trifluoro-1-(methylamino)ethyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 14 h / 20 °C

2.1: triethylamine / titanium(IV) isopropylate / ethanol / 20 °C

2.2: 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

With hydrogen; Dess-Martin periodane; triethylamine; titanium(IV) isopropylate; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;