1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

Base Information

Chemical Name:1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine
CAS No.:1283526-67-9
Molecular Formula:C₁₄H₁₉F₃N₂O₃
Molecular Weight:320.312
Hs Code.:

Synonyms:1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

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Chemical Property of 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

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Technology Process of 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

There total 4 articles about 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1283526-66-8
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanone

: 1283526-67-9
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

Guidance literature:: 1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanone; With triethylamine; titanium(IV) isopropylate; In ethanol; at 20 ℃;

With sodium tetrahydroborate; at 0 - 20 ℃;

Reference yield:

: 2725-53-3
2-hydroxy-5-t-butylbenzaldehyde

: 1283526-67-9
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitronium tetrafluoborate / acetonitrile / 1 h / -40 - -20 °C

1.2: 15 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2.2: 2 h / 20 °C

3.1: Dess-Martin periodane / dichloromethane / 14 h / 20 °C

4.1: triethylamine / titanium(IV) isopropylate / ethanol / 20 °C

4.2: 0 - 20 °C

With nitronium tetrafluoborate; tetrabutyl ammonium fluoride; Dess-Martin periodane; triethylamine; titanium(IV) isopropylate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1283526-57-7
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoroethanol

: 1283526-67-9
1-(5-tert-butyl-2-methoxy-3-nitrophenyl)-2,2,2-trifluoro-N-methylethaneamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 14 h / 20 °C

2.1: triethylamine / titanium(IV) isopropylate / ethanol / 20 °C

2.2: 0 - 20 °C

With Dess-Martin periodane; triethylamine; titanium(IV) isopropylate; In ethanol; dichloromethane;