tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate
CAS No.:1601482-71-6
Molecular Formula:C₂₄H₃₅F₂N₃O₅S
Molecular Weight:515.622
Hs Code.:

Synonyms:tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

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Chemical Property of tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

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Technology Process of tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

There total 10 articles about tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 951127-25-6
N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester

: 1181267-43-5
2-(methylsulfonyl)-2,7-diazaspiro[4.4]nonane

: 1601482-71-6
tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: With nido-decaborane; In methanol; at 25 - 30 ℃; for 15h; Inert atmosphere;

Reference yield:

: 951127-27-8
1-(2,5-difluorophenyl)-2-nitroethanone

: 1601482-71-6
tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl acetamide / 4 h / 25 - 30 °C

2: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C

3: hydrogenchloride; zinc / water; ethanol / 1 h / 0 °C

4: methanol / 15 h / 25 °C

5: sodium carbonate / water; acetonitrile / 2 h / 0 - 30 °C

6: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile; dichloromethane / 3 h / 25 °C

7: nido-decaborane / methanol / 15 h / 25 - 30 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; nido-decaborane; ruthenium(III) chloride trihydrate; sodium carbonate; caesium carbonate; zinc; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: 951127-28-9
6-(2,5-difluorophenyl)-3-methylidene-5-nitro-3,4-dihydro-2H-pyran

: 1601482-71-6
tert-butyl ((2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7-(methylsulfonyl)-2,7-diazaspiro[4.4]nonan-2-yl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C

2: hydrogenchloride; zinc / water; ethanol / 1 h / 0 °C

3: methanol / 15 h / 25 °C

4: sodium carbonate / water; acetonitrile / 2 h / 0 - 30 °C

5: sodium periodate; ruthenium(III) chloride trihydrate / water; acetonitrile; dichloromethane / 3 h / 25 °C

6: nido-decaborane / methanol / 15 h / 25 - 30 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; nido-decaborane; ruthenium(III) chloride trihydrate; sodium carbonate; zinc; In methanol; ethanol; dichloromethane; water; acetonitrile;