(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

Base Information

Chemical Name:(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine
CAS No.:1386985-95-0
Molecular Formula:C₁₅H₁₁BrF₂N₂O₄S
Molecular Weight:433.23
Hs Code.:

Synonyms:(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

Chemical Property:

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Technology Process of (R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

There total 2 articles about (R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386985-92-7
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-1-fluoromethyl-2-hydroxy-ethyl]-2-nitro-benzenesulfonamide

: 1386985-95-0
(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2.5h;

Reference yield:

: C₂₀H₂₁BrF₂N₂O₆S

: 1386985-95-0
(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid; methanol / tetrahydrofuran / 6 h

2: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2.5 h / 0 - 20 °C

With methanol; camphor-10-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene;

Reference yield:

: 1386985-95-0
(R)-2-(5-bromo-2-fluoro-phenyl)-2-fluoromethyl-1-(2-nitro-benzenesulfonyl)-aziridine

: 1386984-45-7
5-cyano-3-methyl-pyridine-2-carboxylic acid [3-((R)-5-amino-3,6,6-tris-fluoromethyl-3,6-dihydro-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h / 20 °C

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 20 °C

4.1: mercaptoacetic acid; potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

5.1: Hexamethyldisiloxane; phosphorous (V) sulfide / toluene / 4 h / 100 °C

6.1: ammonia / methanol / 72 h / 80 °C / Sealed tube

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C

8.1: sodium azide; copper(l) iodide; sodium L-ascorbate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / ethanol; water / 70 °C / Inert atmosphere

9.1: hydrogen / 5%-palladium/activated carbon / ethanol; tetrahydrofuran

10.1: 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

11.1: trifluoroacetic acid / dichloromethane / 1 h

With 4-methyl-morpholine; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; sodium azide; 1-hydroxy-7-aza-benzotriazole; Hexamethyldisiloxane; ammonia; water; hydrogen; phosphorous (V) sulfide; chloroformic acid ethyl ester; sodium hydride; potassium carbonate; mercaptoacetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;