(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

Base Information

Chemical Name:(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one
CAS No.:1386985-97-2
Molecular Formula:C₁₉H₁₅BrF₄N₂O₆S
Molecular Weight:555.302
Hs Code.:

Synonyms:(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

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Chemical Property of (R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

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Technology Process of (R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

There total 4 articles about (R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386985-98-3
C₁₉H₁₇BrF₄N₂O₇S

: 1386985-97-2
(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

Guidance literature:: With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: C₂₀H₂₁BrF₂N₂O₆S

: 1386985-97-2
(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: camphor-10-sulfonic acid; methanol / tetrahydrofuran / 6 h

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2.5 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 25 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h / 20 °C

5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; methanol; camphor-10-sulfonic acid; water; chloroformic acid ethyl ester; sodium hydride; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1386985-96-1
2-[(R)-2-(5-bromo-2-fluoro-phenyl)-3-fluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-3-fluoro-2-fluoromethyl-propionic acid ethyl ester

: 1386985-97-2
(R)-5-(5-bromo-2-fluoro-phenyl)-2,2,5-tris-fluoromethyl-4-(2-nitro-benzenesulfonyl)-morpholin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h / 20 °C

2: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; water; chloroformic acid ethyl ester; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;