(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

Base Information

Chemical Name:(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate
CAS No.:1612891-50-5
Molecular Formula:C₁₆H₁₉F₃N₂O₂S
Molecular Weight:360.4
Hs Code.:

Synonyms:(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

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Technology Process of (2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

There total 10 articles about (2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1612891-48-1
(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

: 1612891-50-5
(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: With tetraphosphorus decasulfide; In tetrahydrofuran; at 50 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-45-8
tert-butyl {[(2S,3R)-3-bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}carbamate

: 1612891-50-5
(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol

2: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

3: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: tetraphosphorus decasulfide / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

With tetraphosphorus decasulfide; 20% palladium hydroxide-activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-46-9
tert-butyl [(2S,3R)-3-amino-1,1,1-trifluoro-3-phenylpropan-2-yl]carbamate

: 1612891-50-5
(2S,3R)-tert-butyl-3-phenyl-5-thioxo-2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

2: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: tetraphosphorus decasulfide / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

With tetraphosphorus decasulfide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j