(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Base Information

Chemical Name:(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate
CAS No.:1612891-48-1
Molecular Formula:C₁₆H₁₉F₃N₂O₃
Molecular Weight:344.334
Hs Code.:

Synonyms:(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Suppliers and Price of (2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

There total 9 articles about (2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1612891-47-0
C₁₆H₂₀ClF₃N₂O₃

: 1612891-48-1
(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-45-8
tert-butyl {[(2S,3R)-3-bis(4-methoxybenzyl)amino]-1,1,1-trifluoro-3-phenylpropan-2-yl}carbamate

: 1612891-48-1
(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen / methanol

2: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

3: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 20% palladium hydroxide-activated charcoal; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j

Reference yield:

: 1612891-46-9
tert-butyl [(2S,3R)-3-amino-1,1,1-trifluoro-3-phenylpropan-2-yl]carbamate

: 1612891-48-1
(2S,3R)-tert-butyl 5-oxo-3-phenyl 2-(trifluoromethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 1.5 h / 0 °C / Inert atmosphere

2: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo500832j