Technology Process of 5-methyl-2-(6-phenyl-5-(trifluoromethyl)pyridin-3-ylamino)benzoic acid
There total 8 articles about 5-methyl-2-(6-phenyl-5-(trifluoromethyl)pyridin-3-ylamino)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(I) oxide; copper; potassium carbonate;
In
1,2-dimethoxyethane;
at 130 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / 5 % platinum on carbon; zinc dibromide / ethyl acetate / 20 h
2.1: hydrogen bromide / 100 °C
2.2: 0 °C / pH 10
3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C
4.1: sodium hydroxide; ethanol; water / 3 h / 110 °C
5.1: copper(I) oxide; copper; potassium carbonate / 1,2-dimethoxyethane / 130 °C
With
copper(I) oxide; sodium hydroxide; ethanol; water; hydrogen bromide; hydrogen; copper; potassium carbonate; caesium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5 % platinum on carbon; zinc dibromide;
In
1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: phosphorus pentachloride; trichlorophosphate / 0.75 h / 140 °C
2.1: copper(l) iodide / N,N-dimethyl-formamide / 19 h / 70 °C
3.1: hydrogen / 5 % platinum on carbon; zinc dibromide / ethyl acetate / 20 h
4.1: hydrogen bromide / 100 °C
4.2: 0 °C / pH 10
5.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 110 °C
6.1: sodium hydroxide; ethanol; water / 3 h / 110 °C
7.1: copper(I) oxide; copper; potassium carbonate / 1,2-dimethoxyethane / 130 °C
With
copper(I) oxide; sodium hydroxide; copper(l) iodide; ethanol; phosphorus pentachloride; water; hydrogen bromide; hydrogen; copper; potassium carbonate; caesium carbonate; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5 % platinum on carbon; zinc dibromide;
In
1,4-dioxane; 1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;
