1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

Base Information

Chemical Name:1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea
CAS No.:1623153-69-4
Molecular Formula:C₂₃H₂₆N₆O₄S
Molecular Weight:482.563
Hs Code.:

Synonyms:1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

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Chemical Property of 1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

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Technology Process of 1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

There total 7 articles about 1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 959616-35-4
1-(2-(4-aminopiperidin-1-yl)ethyl)-7-methoxy-1,5-naphthyridin-2(1H)-one

: 2131-61-5
p-nitrophenyl isothiocyanate

: 1623153-69-4
1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.08.018

Reference yield:

: 884495-37-8
2-chloro-5-fluoro-3-nitropyridine

: 1623153-69-4
1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

Guidance literature:: Multi-step reaction with 7 steps

1: N-Methyldicyclohexylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; palladium diacetate / 4 h / 150 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Sealed tube

3: dichloromethane; pyridine / 0.5 h / -20 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Sealed tube

5: methanol / 3 h / 65 °C

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

7: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; N-Methyldicyclohexylamine; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; In 1,4-dioxane; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Heck Reaction;
DOI:10.1016/j.ejmech.2014.08.018

Reference yield:

: 959615-64-6
7-fluoro-1,5-naphthyridin-2(1H)-one

: 1623153-69-4
1-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-nitrophenyl)thiourea

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C / Sealed tube

2: dichloromethane; pyridine / 0.5 h / -20 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C / Sealed tube

4: methanol / 3 h / 65 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 0 °C

6: triethylamine / dichloromethane / 12 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; caesium carbonate; triethylamine; In 1,4-dioxane; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.08.018