Welcome to LookChem.com Sign In|Join Free

CAS

  • or

959615-64-6

Post Buying Request

959615-64-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

959615-64-6 Usage

General Description

Naphthyridone7 is a chemical compound that belongs to the naphthyridone family, and specifically refers to the seventh member in this series. It is often used in research and development of pharmaceuticals and agrochemicals, due to its unique structure and potential biological activities. Naphthyridone7 has been studied for its antibacterial and antiviral properties, and has shown promise in inhibiting certain enzymes or biochemical pathways in microorganisms. Its versatility and potential applications make it an important target for further investigation and potential drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 959615-64-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,6,1 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 959615-64:
(8*9)+(7*5)+(6*9)+(5*6)+(4*1)+(3*5)+(2*6)+(1*4)=226
226 % 10 = 6
So 959615-64-6 is a valid CAS Registry Number.

959615-64-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-fluoro-1H-1,5-naphthyridin-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:959615-64-6 SDS

959615-64-6Relevant articles and documents

A one-pot diazotation-fluorodediazoniation reaction and fluorine gas for the production of fluoronaphthyridines

Abele, Stefan,Schmidt, Gunther,Fleming, Matthew J.,Steiner, Heinz

, p. 993 - 1001 (2014/10/15)

Several synthetic routes to 7-fluoro-2-methoxy-8-methyl-1,5-naphthyridine (1) are presented, and their suitability for scale-up is discussed. The way of introducing the fluorine atom is crucial. Early routes start from commercially available fluorinated building blocks or employ F+ reagents like SelectFluor and delivered up to 70 kg of 7-fluoro-2-methoxy-1,5-naphthyridine (18). To prepare for larger scales, the focus turned to the use of HF or elemental fluorine, both one of the cheapest sources of fluorine. The first method, a one-pot diazotation-fluorodediazoniation with 6-methoxy-1,5- naphthyridin-3-amine (9) in HF gave the fluorinated naphthyridine 18 in high yield and purity without isolation of the unstable diazonium salt, the latter being a severe drawback of the related Balz-Schiemann protocol. The second method relies on the use of fluorine gas for a surprisingly selective ortho-fluorination of 6-methoxy-1,5-naphthyridin-4-ol (10).

Benzimidazoles: Novel mycobacterial gyrase inhibitors from scaffold morphing

Hameed P, Shahul,Raichurkar, Anandkumar,Madhavapeddi, Prashanti,Menasinakai, Sreenivasaiah,Sharma, Sreevalli,Kaur, Parvinder,Nandishaiah, Radha,Panduga, Vijender,Reddy, Jitendar,Sambandamurthy, Vasan K.,Sriram

supporting information, p. 820 - 825 (2014/08/05)

Type II topoisomerases are well conserved across the bacterial species, and inhibition of DNA gyrase by fluoroquinolones has provided an attractive option for treatment of tuberculosis (TB). However, the emergence of fluoroquinolone-resistant strains of Mycobacterium tuberculosis (Mtb) poses a threat for its sustainability. A scaffold hopping approach using the binding mode of novel bacterial topoisomerase inhibitors (NBTIs) led to the identification of a novel class of benzimidazoles as DNA gyrase inhibitors with potent anti-TB activity. Docking of benzimidazoles to a NBTI bound crystal structure suggested that this class of compound makes key contacts in the enzyme active site similar to the reported NBTIs. This observation was further confirmed through the measurement of DNA gyrase inhibition, and activity against Mtb strains harboring mutations that confer resistance to aminopiperidines based NBTIs and Mtb strains resistant to moxifloxacin. Structure-activity relationship modification at the C-7 position of the left-hand side ring provided further avenue to improve hERG selectivity for this chemical series that has been the major challenges for NBTIs.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 959615-64-6