2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

Base Information

Chemical Name:2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline
CAS No.:213541-04-9
Molecular Formula:C₂₅H₁₈ClF₂NO₂
Molecular Weight:437.873
Hs Code.:

Synonyms:2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

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Chemical Property of 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

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Technology Process of 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

There total 7 articles about 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 213541-02-7
2-[4-(2-fluorophenyl)phenyl]-3-(2-methoxycarbonylethyl)-4-chloromethyl-6-fluoroquinoline

: 213541-04-9
2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

Guidance literature:: With hydrogenchloride; In acetic acid; at 55 ℃; for 2h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 213541-04-9
2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

4.1: SOCl₂; DMF / toluene / 2 h / 55 °C

4.2: 75 percent / NaBH₄ / tetrahydrofuran / 1.5 h / 20 °C

5.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 20 °C

6.1: 98 percent / conc. HCl / acetic acid / 2 h / 55 °C

With hydrogenchloride; potassium hydroxide; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 321-60-8
2-fluorobiphenyl

: 213541-04-9
2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

4.1: SOCl₂; DMF / toluene / 2 h / 55 °C

4.2: 75 percent / NaBH₄ / tetrahydrofuran / 1.5 h / 20 °C

5.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 20 °C

6.1: 98 percent / conc. HCl / acetic acid / 2 h / 55 °C

With hydrogenchloride; potassium hydroxide; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; acetic acid; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3