(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

Base Information

Chemical Name:(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate
CAS No.:1449475-92-6
Molecular Formula:C₃₃H₄₁N₃O₅
Molecular Weight:559.706
Hs Code.:

Synonyms:(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

Suppliers and Price of (S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

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Technology Process of (S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

There total 7 articles about (S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 1449475-91-5
N-1-benzyl-4-tert-butylbenzene-1,2-diamine

: 1449475-92-6
(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; at 15 ℃; for 3h;

Reference yield:

: 6310-19-6
4-tert-butyl-2-nitroaniline

: 1449475-92-6
(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / toluene; dimethyl sulfoxide / 0.67 h / 20 °C / Large scale

1.2: 4 h / 10 °C / Large scale

2.1: methanol / 0.17 h / Large scale

2.2: Raney nickel / 10 h / 20 °C / Large scale

3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 3 h / 15 °C

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; potassium hydroxide; In methanol; dimethyl sulfoxide; ethyl acetate; toluene;

Reference yield:

: 40655-37-6
N-(4-(tert-butyl)-2-nitrophenyl)acetamide

: 1449475-92-6
(S)-benzyl-4-(2-benzylamino)-3-tert-butylphenylamino-3-(tert-butyxoycarbonylamino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium methylate / 2 h / 20 °C / Reflux; Large scale

2.1: potassium hydroxide / toluene; dimethyl sulfoxide / 0.67 h / 20 °C / Large scale

2.2: 4 h / 10 °C / Large scale

3.1: methanol / 0.17 h / Large scale

3.2: Raney nickel / 10 h / 20 °C / Large scale

4.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 3 h / 15 °C

With methanol; sodium methylate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; potassium hydroxide; In methanol; dimethyl sulfoxide; ethyl acetate; toluene;