2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

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Chemical Name:2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide
CAS No.:1361581-76-1
Molecular Formula:C₃₁H₄₇N₅O₅S
Molecular Weight:601.811
Hs Code.:

2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

Synonyms:2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

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Chemical Property of 2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

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Technology Process of 2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

There total 10 articles about 2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

: N-methyl-4-(4-methylpiperazin-1-yl)cyclohexanamine hydrochloride

: 1361581-76-1
2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

Guidance literature:: 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

N-methyl-4-(4-methylpiperazin-1-yl)cyclohexanamine hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 32.0%

: 1242850-00-5
2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid

: 1361582-70-8
N-Methyl-4-(4-methylpiperazin-1-yl)cyclohexanamine hydrochloride

: 1361581-76-1
2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

Guidance literature:: 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

N-Methyl-4-(4-methylpiperazin-1-yl)cyclohexanamine hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 73627-16-4
N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

: 1361581-76-1
2-[[2-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazin-1-yl]-methoxy]-N-methyl-N-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / water / 24 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

3.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

3.2: pH > 7

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4.2: 0 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / tetrahydrofuran / 20 °C

6.2: 0 - 20 °C

7.1: potassium hydroxide; water / ethanol / 16 h / 20 °C

7.2: pH 3

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h / 0 °C

8.2: 0 - 20 °C

With lithium aluminium tetrahydride; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;