n-(3-Hydroxybutyl)benzamide

Base Information

• Chemical Name: n-(3-Hydroxybutyl)benzamide
• CAS No.: 6638-38-6
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.2423
• NSC Number: 48052
• DSSTox Substance ID: DTXSID10286858

Synonyms:6638-38-6;n-(3-hydroxybutyl)benzamide;NSC48052;DTXSID10286858;NSC-48052;AKOS013772204

Chemical Property of n-(3-Hydroxybutyl)benzamide

Chemical Property:

• Vapor Pressure: 1.3E-07mmHg at 25°C
• Boiling Point: 414.5°Cat760mmHg
• Flash Point: 204.5°C
• Density: 1.09g/cm³
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCNC(=O)C1=CC=CC=C1)O

Technology Process of n-(3-Hydroxybutyl)benzamide

There total 2 articles about n-(3-Hydroxybutyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoyl chloride (98-88-4) + 2-hydroxy-butylamine (13552-21-1) + 4-amino-butan-2-ol (114963-62-1,127912-49-6,39884-48-5) → N-(2-hydroxybutyl)benzamide (19278-47-8) + N-(3-hydroxybutyl)benzamide (6638-38-6)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; Overall yield = 32 %;

DOI:10.1021/acs.orglett.6b03731

Reference yield:

N-benzoyl-1-aminobutan-3-one (71666-56-3) → N-(3-hydroxybutyl)benzamide (6638-38-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2009.02.023

Reference yield: 61.0%

N-(3-hydroxybutyl)benzamide (6638-38-6) + phenylcarbonochloridothioate (1005-56-7) → O-(4-benzamidobutan-2-yl) O-phenyl carbonothioate

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.0c04039

upstream raw materials:

N-benzoyl-1-aminobutan-3-one

benzoyl chloride

2-hydroxy-butylamine

4-amino-butan-2-ol

Downstream raw materials:

6-methyl-2-phenyl-5,6-dihydro-4H-[1,3]thiazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 6638-38-6 N-(3-hydroxybutyl)benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send