13552-21-1

Usage

Uses

Used in Pharmaceutical Industry:
1-AMINO-2-BUTANOL is used as an intermediate for the synthesis of various pharmaceutical compounds, such as antibiotics, antifungal agents, and other therapeutic drugs. Its versatility in chemical reactions and ability to form stable derivatives make it a valuable component in the development of new medications.
Used in Chemical Industry:
1-AMINO-2-BUTANOL serves as a building block for the production of various chemicals, including surfactants, emulsifiers, and additives. Its compatibility with a range of other chemicals allows for the creation of diverse products with specific properties tailored to various applications.
Used in Cosmetics Industry:
In the cosmetics industry, 1-AMINO-2-BUTANOL is used as a humectant, helping to retain moisture in skincare and hair care products. Its ability to form stable emulsions also makes it a useful ingredient in the formulation of creams, lotions, and other personal care products.
Used in Food and Beverage Industry:
1-AMINO-2-BUTANOL is utilized as a flavor enhancer and additive in the food and beverage industry. Its unique taste and ability to blend well with other ingredients contribute to the overall flavor profile of various products, such as beverages, confections, and savory snacks.
Used in Research and Development:
1-AMINO-2-BUTANOL is employed as a research compound in the development of new materials, catalysts, and other innovative technologies. Its unique chemical properties make it an interesting subject for scientific exploration and potential applications in various fields.

Air & Water Reactions

Avoid exposing 1-AMINO-2-BUTANOL to air for prolonged periods of time . Water soluble.

Reactivity Profile

1-AMINO-2-BUTANOL is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data are not available for 1-AMINO-2-BUTANOL, but 1-AMINO-2-BUTANOL is probably combustible.

Upstream product

• 106-88-7 ethyloxirane 
• 3156-74-9 1-nitro-2-butanol 
• 4476-02-2 2-hydroxybutanenitrile 
• 152264-24-9 1-azido-2-butanol 
• 89333-64-2 2-((E)-But-2-enyl)-1,1,1,3,3,3-hexamethyl-disilazane 
• 7647-01-0 hydrogenchloride 
• 77369-28-9 1-amino-2-butanone 
• 109-73-9 N-butylamine 
• 89479-94-7 (R)(-)-1-N-benzylaminobutan-2-ol 
• 106-88-7 (R)-(+)-1,2-epoxybutane 

Downstream Products

• 101721-43-1 1-(4-nitro-benzoylamino)-2-(4-nitro-benzoyloxy)-butane 
• 96608-29-6 1-benzoylamino-2-benzoyloxy-butane 
• 700348-58-9 1-(2-hydroxybutyl)-3-phenylthiourea 
• 7467-68-7 1-([9]anthrylmethyl-amino)-butan-2-ol 
• 96835-55-1 2,2'-dithiobis 
• 141334-67-0 (S)-2-Benzyloxycarbonylamino-4-(2-hydroxy-butylcarbamoyl)-butyric acid tert-butyl ester 
• 93040-62-1 (E)-N-(2-Hydroxy-butyl)-3-(3-trifluoromethyl-phenyl)-acrylamide 
• 73480-61-2 2-Benzylamino-N-(2-hydroxy-butyl)-benzamide 
• 80537-01-5 2-Phenyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid (2-hydroxy-butyl)-amide 
• 89585-14-8 2-ethoxy-butylamine 
• 857832-26-9 (2-ethoxy-ethyl)-(2-ethoxy-butyl)-amine 
• 857824-99-8 bis-(2-ethoxy-ethyl)-(2-ethoxy-butyl)-amine 
• 224441-62-7 1-[(benzyloxycarbonyl)amino]-2-butanol 
• 884498-45-7 tert-butyl {(3R,6S)-6-(2,3-difluorophenyl)-2-[(2-hydroxybutyl)imino]azepan-3-yl}carbamate 

Relevant academic research and scientific papers

Formation of potentially prebiotic amphiphiles by reaction of β-hydroxy-n-alkylamines with cyclotriphosphate

(Chemical Equation Presented) The long and the short of it: In water, long-chain β-hydroxy-n-alkylamines are converted to their O-monophosphates by reaction with cyclotriphosphate. With short-chain pVhydroxy-n-alkylamines, N-triphosphates are formed instead. The difference results from the formation of surfactant assemblies from the long-chain compounds. This surfactant control of reactivity may be of relevance to the prebiotic formation of amphiphiles. P: phosphate unit.

INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS

The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acc

Chiral-Organotin-Catalyzed Kinetic Resolution of Vicinal Amino Alcohols

A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin compound with 3,4,5-trifluorophenyl groups at the 3,3′-positions of the binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl- and alkyl-substituted amino alcohols and a variety of other substrates, affording the corresponding products in high enantioselectivity and with s factors up to >500.

BISARYL AMIDES AS NRF2 REGULATORS

The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I).

BISARYL HETEROCYCLES AS NRF2 ACTI

The present invention relates to bisaryl heterocycle compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I),

NRF2 COMPOUNDS

The present invention relates to a compound which is (R)-3-(1,4- dimethyl-1 H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3- dihydropyrido[2,3-f][l,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl) propanoic acid (I), or a pharmaceutically acceptable salt

ETHER LINKED TRIAZOLES AS NRF2 REGULATORS

The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:

The hydrolysis of epoxides catalyzed by inorganic ammonium salts in water: Kinetic evidence for hydrogen bond catalysis

Naturally-occurring inorganic ammonium ions have been recently reported as efficient catalysts for some organic reactions in water, which contributes to the understanding of the chemistry in some natural environments (soils, seawater, atmospheric aerosols, .) and biological systems, and is also potentially interesting for green chemistry as many of their salts are cheap and non-toxic. In this work, the effect of NH4+ ions on the hydrolysis of small epoxides in water was studied kinetically. The presence of NH4+ increased the hydrolysis rate by a factor of 6 to 25 compared to pure water and these catalytic effects were shown not to result from other ions, counter-ions or from acid or base catalysis, general or specific. The small amounts of amino alcohols produced in the reactions were identified as the actual catalysts by obtaining a strong acceleration of the reactions when adding these compounds directly to the epoxides in water. Replacing the amino alcohols by other strong hydrogen-bond donors, such as trifluoroethanol (TFE) or hexafluoroisopropanol (HFIP) gave the same results, demonstrating that the kinetics of these reactions was driven by hydrogen-bond catalysis. Because of the presence of many hydrogen-bond donors in natural environments (for instance amines and hydroxy-containing compounds), hydrogen-bond catalysis is likely to contribute to many reaction rates in these environments.

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.