1,4-dimethoxy-10H-acridine-9-thione

Base Information

Chemical Name:1,4-dimethoxy-10H-acridine-9-thione
CAS No.:141992-47-4
Molecular Formula:C₁₅H₁₃NO₂S
Molecular Weight:271.34
Hs Code.:
NSC Number:625987
UNII:X5RCK1XO4F
DSSTox Substance ID:DTXSID90161912
Nikkaji Number:J480.144J
Wikidata:Q27075829
Pharos Ligand ID:5DB3TJVX23P1
ChEMBL ID:CHEMBL1331734
Mol file:141992-47-4.mol

Synonyms:NSC 625987;141992-47-4;1,4-dimethoxy-10H-acridine-9-thione;NSC625987;NSC-625987;1,4-Dimethyoxy-9(10H)-acridinone;Cdk4 inhibitor II;X5RCK1XO4F;1,4-Dimethoxy-9(10H)-acridinethione;1,4-dimethoxy-9,10-dihydroacridine-9-thione;1,4-Dimethoxyacridine-9(10H)-thione;Tocris-2152;UNII-X5RCK1XO4F;D0VD8B;GTPL5951;SCHEMBL1985563;CHEMBL1331734;BDBM59089;DTXSID90161912;CHEBI:114175;HMS2043P07;HMS3229E06;HMS3268N07;HMS3413I05;HMS3677I05;9(10H)-Acridinethione,4-dimethoxy-;AKOS022488648;CCG-206829;SMP2_000076;NCGC00025358-01;MS-23842;NCI60_008225;HY-103380;CS-0027779;FT-0711674;E98772;NSC 625987, >=97% (HPLC);SR-01000597535;J-007574;SR-01000597535-1;BRD-K62949423-001-02-3;Q27075829;Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4

Suppliers and Price of 1,4-dimethoxy-10H-acridine-9-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NSC625987
25mg
$ 265.00

Sigma-Aldrich
Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem
5mg
$ 169.00

ApexBio Technology
NSC625987
50mg
$ 1221.00

ApexBio Technology
NSC625987
10mg
$ 282.00

American Custom Chemicals Corporation
1,4-DIMETHOXY-10H-ACRIDINE-9-THIONE 95.00%
50MG
$ 1230.95

American Custom Chemicals Corporation
1,4-DIMETHOXY-10H-ACRIDINE-9-THIONE 95.00%
10MG
$ 245.70

Total 12 raw suppliers

Chemical Property of 1,4-dimethoxy-10H-acridine-9-thione

Chemical Property:

Vapor Pressure:1.17E-08mmHg at 25°C
Boiling Point:460.4°C at 760 mmHg
Flash Point:232.2°C
PSA：66.34000
Density:1.32g/cm³
LogP:4.06780
Storage Temp.:2-8°C
Solubility.:DMSO: 14 mg/mL
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:271.06669983
Heavy Atom Count:19
Complexity:349

Purity/Quality:

99%, ^*data from raw suppliers

NSC625987 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C2C(=C(C=C1)OC)NC3=CC=CC=C3C2=S
Uses NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor.

Technology Process of 1,4-dimethoxy-10H-acridine-9-thione

There total 4 articles about 1,4-dimethoxy-10H-acridine-9-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 25379-15-1
1,4-dimethoxy-9-(10H)-acridinone

: 141992-47-4
NSC 625987

Guidance literature:: With tetraphosphorus decasulfide; In pyridine; for 24h; Heating;

Reference yield:

: 21193-37-3
2-[(2,5-dimethoxyphenyl)amino]benzoic acid

: 141992-47-4
NSC 625987

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃

2: P₄S₁₀, HMPT

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetraphosphorus decasulfide; trichlorophosphate;

Reference yield:

: 102-56-7,102526-87-4
2,5-dimethoxyaniline

: 141992-47-4
NSC 625987

Guidance literature:: Multi-step reaction with 3 steps

1: Cu / Heating

2: POCl₃

3: P₄S₁₀, HMPT

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetraphosphorus decasulfide; copper; trichlorophosphate;