21193-37-3Relevant academic research and scientific papers
Synthesis and preliminary cytotoxic activity of dimethoxyacridines and dimethoxynitroacridines
Monge,Martinez-Crespo,Santamaria,Narro,Lopez De Cerain,Hamilton,Barker
, p. 1455 - 1460 (1994)
The preparation of a series of dimethoxy and dimethoxynitroacridines and their activity in oxic and hypoxic cells is reported. Anthranilic acids 1, 4, 14 were prepared according to the Ullmann condensation. 9-chloroacridines were obtained from anthranilic
Synthesis of acridine-quinone systems - A potential electrochemical fluorescent switch
Litchfield, Verity J.,Smith, Robert B.,Franklin, Anthony M.,Davis, James
, p. 3447 - 3455 (2008/12/23)
The synthesis of various acridine-quinones is reported. The fluorescence-quenching quinone moiety has been incorporated into various acridine molecules, each having a different functionality at the ninth position of the acridine ring. It is envisaged that
Convenient access to substituted acridines by a Buchwald-Hartwig amination
Csuk, René,Barthel, Alexander,Raschke, Christian
, p. 5737 - 5750 (2007/10/03)
A convenient, high yield procedure for the synthesis of anthranilic acids carrying a variety of different substituents as well as their straightforward transformation into the corresponding 9-chloroacridines could be established by using modified Buchwald-Hartwig amination conditions.
Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds
Delfourne, Evelyne,Kiss, Robert,Le Corre, Laurent,Merza, Joumaa,Bastide, Jean,Frydman, Armand,Darro, Francis
, p. 4351 - 4356 (2007/10/03)
The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different related compounds were prepared and tested in vitro at six different concentrations on 12 different human cancer cell lines of various histopathological types (glioblastomas and breast, colon, lung, prostate and bladder cancers). Almost all the compounds present cytotoxic activity of micromolar order.
Synthesis of ascididemine and an isomer
Alvarez, Mercedes,Feliu, Lidia,Ajana, Wadi,Joule, John A.,Fernandez-Puentes, Jose Luis
, p. 849 - 855 (2007/10/03)
Ascididemine (9H-quino[4,3,2-de][1,10]phenanthrolin-9-one) (1) and an isomer (9H-quino[4,3,2-de][1,7]phenanthrolin-9-one) (4) have been synthesized starting from 1,4-dimethoxyacridone (7). The acridone was converted into 1,4- dimethoxy-9-ethynylacridine (
Synthesis of benzacridine and pyridoacridine via Diels-Alder reaction of acridonequinone
Horiguchi, Yoshie,Sakuma, Shinichi,Suzuki, Hideki,Sano, Takehiro
, p. 1305 - 1316 (2007/10/03)
Synthesis of benz[b]acridones (8) and pyrido[3,2-b]acridones (15) was achieved by Diels-Alder reaction of acridonequinones (5) with several activated 1,3-dienes. The addition proceeded in a regioselective manner under mild conditions, thus providing a con
Structure-trypanodical activity relationships
Bsiri,Johnson,Kayirere,Galy,Galy,Barbe,Osuna,Mesa-Valle,Castilla Calvente,Rodriguez-Cabezas
, p. 27 - 33 (2007/10/03)
A set of 9-thioalkylacridinones, has been prepared and investigated' in vitro' against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.
