1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide
CAS No.:1612148-46-5
Molecular Formula:C₃₁H₃₁ClN₄O₃
Molecular Weight:543.065
Hs Code.:

Synonyms:1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

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Chemical Property of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

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Technology Process of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

There total 6 articles about 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1146757-92-7
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 2-aminoadamantane hydrochloride

: 1612148-46-5
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; for 16h; Inert atmosphere;

Reference yield: 65.0%

: 1146757-92-7
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 10523-68-9
adamantan-2-amine hydrochloride

: 1612148-46-5
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5003843

Reference yield:

: methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutanoate sodium salt

: 1612148-46-5
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-N-tricyclo-[3.3.1.13,7]dec-2-yl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; hydrogenchloride / water / Inert atmosphere; Reflux

2.1: lithium hydroxide / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; lithium hydroxide; In 1,4-dioxane; dichloromethane; water; 1.1: |Knorr Pyrazole Synthesis;
DOI:10.1021/jm5003843