5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride

Base Information

• Chemical Name: 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride
• CAS No.: 1343413-18-2
• Molecular Formula: C₄₄H₄₆N₂O₃*ClH
• Molecular Weight: 687.322
• Mol file: 1343413-18-2.mol

Synonyms:5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride

Chemical Property of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride

There total 1 articles about 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole (198480-21-6) → 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride (1343413-18-2)

Guidance literature:

With hydrogenchloride; In toluene; at 30 - 70 ℃; for 1h;

Reference yield: 90.0%

5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride (1343413-18-2) → 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole (198480-21-6)

Guidance literature:

With sodium hydroxide; In water; toluene; at 65 - 70 ℃; for 1.5h;

Reference yield:

5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1-[4-(2-azepan-1-ylethoxy)benzyl]-1H-indole hydrochloride (1343413-18-2) → bazedoxifene (198481-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; toluene / 1.5 h / 65 - 70 °C

2: hydrogen / palladium-on-charcoal / ethyl acetate / 30 - 35 °C / 2942.29 - 3677.86 Torr

With hydrogen; sodium hydroxide; palladium-on-charcoal; In water; ethyl acetate; toluene;

upstream raw materials:

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole

Downstream raw materials:

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole

bazedoxifene acetate

bazedoxifene