FAM alkyne, 6-isomer

Base Information

Chemical Name:FAM alkyne, 6-isomer
CAS No.:478801-49-9
Molecular Formula:C₂₄H₁₅NO₆
Molecular Weight:413.386
Hs Code.:

Synonyms:N-(2''-propynyl)-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

Suppliers and Price of FAM alkyne, 6-isomer

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
FAMalkyne,6-isomer 96%
10 MG
$ 140.00

Total 8 raw suppliers

Chemical Property of FAM alkyne, 6-isomer

Chemical Property:

Boiling Point:722.3±60.0 °C(Predicted)
PKA:9.32±0.20(Predicted)
Density:1.58±0.1 g/cm3(Predicted)
Solubility.:Soluble in DMSO, DMF, DCM

Purity/Quality:

99%, ^*data from raw suppliers

FAMalkyne,6-isomer 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description FAM (fluorescein) alkyne is a high purity (96%) 6-isomer with significant aqueous solubility. Alkyne enables copper-catalyzed Click chemistry.

Technology Process of FAM alkyne, 6-isomer

There total 5 articles about FAM alkyne, 6-isomer which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1381804-22-3
N-(2''-propynyl)-3',6'-dipivaloyloxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

: 478801-49-9
N-(2''-propynyl)-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

Guidance literature:: N-(2''-propynyl)-3',6'-dipivaloyloxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide; With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2 - 3;
DOI:10.1016/j.bmcl.2012.04.055

Reference yield:

: 192374-17-7
3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid

: 478801-49-9
N-(2''-propynyl)-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 8 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

2.2: pH 2 - 3

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.055

Reference yield:

: 552-30-7,145253-53-8
trimellitic Anhydride

: 478801-49-9
N-(2''-propynyl)-3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: neat (no solvent) / 4 h / 180 - 220 °C

1.2: 23 h / 20 °C / Inert atmosphere

1.3: 19 h / -20 °C

2.1: hydrogenchloride / water / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / acetonitrile / 7 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 1 h / 0 - 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1002/anie.202016684