Chemical Property of 18,21-Dihydroxypregn-4-ene-3,20-dione
Chemical Property:
- Vapor Pressure:1.06E-13mmHg at 25°C
- Melting Point:171-173 °C
- Refractive Index:1.577
- Boiling Point:535.4 °C at 760 mmHg
- Flash Point:291.7 °C
- PSA：74.60000
- Density:1.22 g/cm3
- LogP:2.66830
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated)
- XLogP3:1.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:3
- Exact Mass:346.21440943
- Heavy Atom Count:25
- Complexity:623
- Purity/Quality:
-
99% *data from raw suppliers
11-Deoxy-18-hydroxycorticosterone *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4C(=O)CO)CO
- Isomeric SMILES:C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)CO
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General Description
18-Hydroxy-11-deoxycorticosterone (18-OHDOC) is an intermediate steroid in the aldosterone biosynthesis pathway, formed from 11-deoxycorticosterone (DOC) via 18-hydroxylation. It is further metabolized to aldosterone by a cortisol-sensitive enzyme system, distinct from the cortisol-insensitive pathway that generates corticosterone (B) and 18-OHDOC from DOC. This suggests 18-OHDOC plays a role in a bifurcated steroidogenic process, where its conversion to aldosterone is regulated differently than its initial formation. The enzyme CYP11B2 (aldosterone synthase) is implicated in the cortisol-sensitive transformation of 18-OHDOC into aldosterone.
