5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione

Base Information

• Chemical Name: 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione
• CAS No.: 1313027-38-1
• Molecular Formula: C₂₂H₂₅N₃O₂S
• Molecular Weight: 395.525

Synonyms:5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione

Chemical Property of 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione

Chemical Property:

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Technology Process of 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione

There total 3 articles about 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(E)-N,N-diallyl-2-(2-(3,4-dimethylphenyl)hydrazono)-4-(thiophen-2-yl)butanamide (1313027-25-6) → 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione (1313027-38-1)

Guidance literature:

With copper diacetate; acetic acid; N,N-dimethyl-formamide; In water; at 80 ℃; for 9h; Inert atmosphere;

DOI:10.1002/ejoc.201100261

Reference yield:

3-(2-thienyl)propanoic acid (5928-51-8) → 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione (1313027-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: pyridine / dichloromethane / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: copper diacetate; acetic acid; N,N-dimethyl-formamide / water / 9 h / 80 °C / Inert atmosphere

With pyridine; oxalyl dichloride; copper diacetate; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water;

DOI:10.1002/ejoc.201100261

Reference yield:

3-(2-thienyl)-propanoic acid chloride (5834-04-8) → 5-allyl-2-(3,4-dimethylphenyl)-6a-(2-(thiophen-2-yl)ethyl)-tetrahydropyrrolo[3,4-c]pyrazole-3,6(3aH,6aH)-dione (1313027-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: copper diacetate; acetic acid; N,N-dimethyl-formamide / water / 9 h / 80 °C / Inert atmosphere

With pyridine; copper diacetate; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water;

DOI:10.1002/ejoc.201100261

upstream raw materials:

3-(2-thienyl)propanoic acid

3-(2-thienyl)-propanoic acid chloride

(E)-N,N-diallyl-2-(2-(3,4-dimethylphenyl)hydrazono)-4-(thiophen-2-yl)butanamide

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