1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Base Information

Chemical Name:1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide
CAS No.:1276126-70-5
Molecular Formula:C₂₂H₁₉F₄N₅O₂
Molecular Weight:461.419
Hs Code.:

Synonyms:1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

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Chemical Property of 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

There total 10 articles about 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276126-64-7
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester

: 1276126-71-6
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

: 1276126-70-5
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Guidance literature:: With amino(methyl)aluminum chloride; In toluene; at 75 ℃;

Reference yield:

: 145733-53-5
2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

: 1276126-70-5
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

2: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

4: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7: amino(methyl)aluminum chloride / toluene / 75 °C

With copper(l) iodide; sodium azide; amino(methyl)aluminum chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 122306-01-8
2-bromo-5-(hydroxymethyl)pyridine

: 1276126-70-5
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

5: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

6: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

8: amino(methyl)aluminum chloride / toluene / 75 °C

With 1H-imidazole; copper(l) iodide; sodium azide; amino(methyl)aluminum chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;