1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

Base Information

Chemical Name:1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile
CAS No.:1276126-71-6
Molecular Formula:C₂₂H₁₇F₄N₅O
Molecular Weight:443.403
Hs Code.:

Synonyms:1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

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Chemical Property of 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

Chemical Property:

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Technology Process of 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

There total 10 articles about 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1276126-64-7
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester

: 1276126-71-6
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

: 1276126-70-5
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid amide

Guidance literature:: With amino(methyl)aluminum chloride; In toluene; at 75 ℃;

Reference yield:

: 145733-53-5
2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

: 1276126-71-6
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

2: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

4: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7: amino(methyl)aluminum chloride / toluene / 75 °C

With copper(l) iodide; sodium azide; amino(methyl)aluminum chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 122306-01-8
2-bromo-5-(hydroxymethyl)pyridine

: 1276126-71-6
1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

5: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

6: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

8: amino(methyl)aluminum chloride / toluene / 75 °C

With 1H-imidazole; copper(l) iodide; sodium azide; amino(methyl)aluminum chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;