Technology Process of 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester
There total 7 articles about 1-(4-fluorophenyl)-6-[4-(1-hydroxy-1-trifluoromethylpropyl)-[1,2,3]triazol-1-ylmethyl]indolizine-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
2: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
4: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C
5: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1H-imidazole / dichloromethane / 0.5 h / 20 °C
2: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 1.5 h / Inert atmosphere; Reflux
3: sodium hydrogencarbonate / acetonitrile / 1.5 h / 135 °C / Inert atmosphere; sealed tube
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h
5: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C
6: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C
7: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
1H-imidazole; copper(l) iodide; sodium azide; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
With
copper(l) iodide; sodium azide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
