2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

Base Information

Chemical Name:2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate
CAS No.:691881-22-8
Molecular Formula:C₁₉H₂₇N₃O₃S₂
Molecular Weight:409.574
Hs Code.:

Synonyms:2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

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Chemical Property of 2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

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Technology Process of 2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

There total 5 articles about 2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 124-63-0
methanesulfonyl chloride

: 691881-21-7
2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethan-1-ol

: 691881-22-8
2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 3446-90-0
4-(methylthio)benzyl alcohol

: 691881-22-8
2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / thionyl chloride / toluene / 0.5 h / 20 °C

2.1: 89 percent / dimethylsulfoxide / 2 h / 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

3.2: 67 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

4.1: 64 percent / glacial AcOH / 1 h / 100 °C

5.1: 64 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With thionyl chloride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 874-87-3
1-(chloromethyl)-4-methylthiobenzene

: 691881-22-8
2-[5-amino-3-cyclohexyl-4-(4-methylthiophenyl)pyrazolyl]ethyl methylsulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / dimethylsulfoxide / 2 h / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 67 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

3.1: 64 percent / glacial AcOH / 1 h / 100 °C

4.1: 64 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

With acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2004.01.012