N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine

Base Information

• Chemical Name: N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine
• CAS No.: 856865-88-8
• Molecular Formula: C₂₁H₂₅N₃O₈S
• Molecular Weight: 479.511
• Mol file: 856865-88-8.mol

Synonyms:N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine

Chemical Property of N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine

There total 4 articles about N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (856865-67-3) → N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine (856865-88-8)

Guidance literature:

With lithium iodide; In ethyl acetate; Heating;

DOI:10.1021/jo050477z

Reference yield:

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride (27894-50-4) → N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine (856865-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

3: 97 percent / LiI / ethyl acetate / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium iodide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine (856865-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

3: 97 percent / LiI / ethyl acetate / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium iodide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

2-Nitrobenzenesulfonyl chloride

N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester