N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Base Information

• Chemical Name: N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester
• CAS No.: 215056-55-6
• Molecular Formula: C₂₁H₂₅N₃O₈S
• Molecular Weight: 479.511
• Mol file: 215056-55-6.mol

Synonyms:N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Chemical Property of N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

There total 1 articles about N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride (27894-50-4) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (215056-55-6)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jo050477z

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (215056-55-6) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (856865-67-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield: 36.0%

(1S,2R,6S)-6-(N-benzyl)-o-nitrobenzenesulfonamino-1,2-di-O-carbonyl-cyclohex-3-ene-1,2-diol (483341-80-6) + N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (215056-55-6) → Nε-benzyloxycarbonyl-Nα-o-nitrobenzenesulfonyl-Nα-[(1R,4R,6S)-6-(N-benzyl)-6-o-nitrobenzenesulfon-amino-cyclohex-2-enol-4-yl]-L-lysine methyl ester

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triethylamine; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2004.01.063

upstream raw materials:

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine