N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Base Information

• Chemical Name: N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester
• CAS No.: 856865-67-3
• Molecular Formula: C₂₂H₂₇N₃O₈S
• Molecular Weight: 493.538
• Mol file: 856865-67-3.mol

Synonyms:N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Chemical Property of N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

There total 3 articles about N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (215056-55-6) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (856865-67-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield:

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride (27894-50-4) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (856865-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-methyl-N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester (856865-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

dimethyl sulfate

N-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine methyl ester

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-ε-benzyloxycarbonyl-L-lysine