Multi-step reaction with 7 steps
1.1: water / ethanol / 4 h / Reflux
2.1: oxalyl dichloride / 2 h / Reflux
3.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C
4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 16 h / 20 °C
5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 0.67 h / -78 - -60 °C / Inert atmosphere
6.1: hydrogenchloride; water / methanol / 2 h / 20 °C
7.1: potassium hydroxide / ethanol; water / 12 h / Reflux
With
hydrogenchloride; ammonium hydroxide; 1,3,5-trichloro-2,4,6-triazine; oxalyl dichloride; water; potassium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-10-12056