(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

Base Information

Chemical Name:(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one
CAS No.:1260522-93-7
Molecular Formula:C₂₅H₃₃NO₆
Molecular Weight:443.54
Hs Code.:

Synonyms:(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

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Chemical Property of (S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

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Technology Process of (S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

There total 16 articles about (S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1260522-92-6
(S)-6-(2-amino-2-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)ethyl)-3-isopropoxy-2-methoxybenzonitrile

: 1260522-93-7
(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: With potassium hydroxide; In ethanol; water; for 12h; Reflux;
DOI:10.3987/COM-10-12056

Reference yield:

: 1260522-87-9
methyl 3-isopropoxy-2-methoxy-6-methylbenzoate

: 1260522-93-7
(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / ethanol / 4 h / Reflux

2.1: oxalyl dichloride / 2 h / Reflux

3.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 0.67 h / -78 - -60 °C / Inert atmosphere

6.1: hydrogenchloride; water / methanol / 2 h / 20 °C

7.1: potassium hydroxide / ethanol; water / 12 h / Reflux

With hydrogenchloride; ammonium hydroxide; 1,3,5-trichloro-2,4,6-triazine; oxalyl dichloride; water; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-10-12056

Reference yield:

: 1260522-84-6
2-(2-(tert-butyldimethylsilyloxy)ethyl)-5-isopropoxy-4-methoxybenzaldehyde

: 1260522-93-7
(S)-3-(2-(2-hydroxyethyl)-5-isopropoxy-4-methoxyphenyl)-7-isopropoxy-8-methoxy-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.67 h / -78 - -60 °C / Inert atmosphere

3.1: hydrogenchloride; water / methanol / 2 h / 20 °C

4.1: potassium hydroxide / ethanol; water / 12 h / Reflux

With titanium(IV) isopropylate; hydrogenchloride; water; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.3987/COM-10-12056