Technology Process of ethyl (3R*,5R*)-methyl>isoxazolidin-3-yl>acetate
There total 10 articles about ethyl (3R*,5R*)-methyl>isoxazolidin-3-yl>acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
for 12h;
Ambient temperature;
DOI:10.1021/jo00270a037
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 91 percent / molecular sieves (4A) / toluene / 14 h / Heating
2: 93 percent / 10percent HCl / methanol / 4 h / 40 °C
3: 86 percent / K2CO3 / dimethylformamide / 1 h / 50 °C
4: 46 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature
5: 76 percent / N-ethyl-N,N-diisopropylamine / CH2Cl2 / 10 h / Ambient temperature
6: 75 percent / dimethylsulfoxide / 4 h / 80 °C
7: 79 percent / hydrogen chloride / 12 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; 4 A molecular sieve; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00270a037
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / K2CO3 / dimethylformamide / 1 h / 50 °C
2: 46 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature
3: 76 percent / N-ethyl-N,N-diisopropylamine / CH2Cl2 / 10 h / Ambient temperature
4: 75 percent / dimethylsulfoxide / 4 h / 80 °C
5: 79 percent / hydrogen chloride / 12 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00270a037
